How to Use Nasdepi®

Needle-Free Epinephrine Nasal Medication for Anaphylaxis Fast Relief Without Needles

Managing a severe allergic reaction shouldn’t be complicated. When anaphylaxis strikes, clarity and speed matter most.

Nasdepi® is being developed as a needle-free epinephrine option that’s designed for simple, rapid intranasal use, especially helpful for people with needle phobia. In this guide, you’ll learn what Nasdepi is, when to use it for severe allergic reactions, and why its design can reduce hesitation in emergencies.

 

What Is Nasdepi®

A Dry-Powder Intranasal Epinephrine Device (An EpiPen® Alternative)

Unlike traditional epinephrine auto-injectors such as EpiPen®, Nasdepi delivers a dry-powder epinephrine dose through the nose. The intranasal route is designed to deliver medication quickly via the nasal mucosa. No needles, no injection technique, and a form factor meant to be intuitive in high-stress moments.

 

When to Use Nasdepi® for Severe Allergic Reactions

Nasdepi is intended for suspected anaphylaxis, which may include symptoms such as breathing difficulty, swelling of the face or throat, severe hives, low blood pressure, dizziness/fainting, or gastrointestinal symptoms after exposure to an allergen. If you or your child has been prescribed epinephrine for Type I (IgE-mediated) allergic reactions, Nasdepi could be part of the emergency action plan once it receives FDA approval.

 

Step-By-Step: How to Use a Needle-Free Epinephrine Nasal Device in an Emergency

• Recognize anaphylaxis and follow your clinician’s allergy action plan.
• Administer the intranasal dose as directed for Nasdepi.
• Call emergency medical services immediately. Epinephrine is first-line, but emergency medical care must follow.
• Monitor symptoms and be prepared to follow the clinician’s guidance for additional care.

 

Why Is Nasdepi® Easy to Use

• No needles: Less hesitation for adults and kids with needle phobia/fear of needles.
• No special training required: Simplified emergency use.
• Heat-resistant: Designed to tolerate a wide range of climates (useful for travel/sports/school).
• Long shelf life: Designed for 3 years (vs. ~1 year for many auto-injectors), helping reduce replacement cost and stress.
• Compact and travel-ready: Slips into a pocket, purse, or backpack.

 

Who Benefits Most: Families, Schools, Travelers and Anyone with Needle Phobia

For parents, teachers, school nurses, camp counselors, and travel companions, a needle-free alternative can reduce fear and speed up action. The intuitive nasal device format supports clear communication when multiple caregivers may need to help.

 

Not Your Typical “Allergy Nasal Spray”: This Is Emergency Epinephrine

While the delivery route is intranasal, Nasdepi is not a daily “allergy nasal spray.” It’s designed for emergency treatment of anaphylaxis, a different category than decongestants or steroid sprays used for routine allergies. Always follow your clinician’s advice and your action plan.

Safety First: Emergency Medical Care Still Comes Next

Nasdepi is not a substitute for professional emergency care. After administering epinephrine, contact emergency services immediately. Nasdepi is an experimental device, currently in clinical trials and targeting future U.S. FDA approval timelines; always consult your healthcare provider about whether intranasal epinephrine is appropriate for you.